● Increase in `color{violet}(Ca^(++))` level leads to the `color{violet}("binding of calcium")` with a subunit of troponin on actin filaments and thereby remove the `color{brown}("masking of active sites")` for `color{violet}("myosin.")`
● Utilising the energy from `color{violet}("ATP hydrolysis,")` the `color{violet}("myosin head ")` now binds to the exposed active sites on actin to form a `color{brown}("cross bridge.")`
● This pulls the attached `color{violet}("actin filaments")` towards the `color{brown}("centre of ‘A’ band.")`
● The`color{violet}(" ‘Z’ line")` attached to these actins are also `color{brown}("pulled inwards")` thereby causing a shortening of the sarcomere, `color{brown}("i.e., contraction.")`
● It is clear from the above steps, that during shortening of the `color{violet}("muscle")`, i.e., contraction, the `color{brown}("‘I’ bands get reduced,")` whereas the `color{brown}("‘A’ bands retain")` the length.
● The `color{violet}("myosin")`, releasing the `color{violet}("ADP and" P_1)` goes back to its relaxed state.
● A new `color{violet}("ATP binds")` and the `color{violet}("cross-bridge is broken.")`
● The ATP is again `color{violet}("hydrolysed")` by the `color{violet}("myosin head")` and the `color{violet}("cycle of cross bridge")` formation and breakage is repeated causing further sliding.
● The process continues till the `color{violet}(Ca^(++))` ions are `color{violet}("pumped back")` to the `color{brown}("sarcoplasmic cisternae")` resulting in the masking of `color{violet}("actin filaments.")`
● This causes the return of `color{violet}("‘Z’ lines")` back to their original position, i.e., `color{brown}("relaxation.")`
● The reaction time of the `color{violet}("fibres")` can vary in `color{violet}("different muscles.")`
● Repeated activation of the `color{violet}("muscles")` can lead to the `color{brown}("accumulation of lactic acid")` due to anaerobic `color{violet}("breakdown of glycogen")` in them, causing fatigue.
● Increase in `color{violet}(Ca^(++))` level leads to the `color{violet}("binding of calcium")` with a subunit of troponin on actin filaments and thereby remove the `color{brown}("masking of active sites")` for `color{violet}("myosin.")`
● Utilising the energy from `color{violet}("ATP hydrolysis,")` the `color{violet}("myosin head ")` now binds to the exposed active sites on actin to form a `color{brown}("cross bridge.")`
● This pulls the attached `color{violet}("actin filaments")` towards the `color{brown}("centre of ‘A’ band.")`
● The`color{violet}(" ‘Z’ line")` attached to these actins are also `color{brown}("pulled inwards")` thereby causing a shortening of the sarcomere, `color{brown}("i.e., contraction.")`
● It is clear from the above steps, that during shortening of the `color{violet}("muscle")`, i.e., contraction, the `color{brown}("‘I’ bands get reduced,")` whereas the `color{brown}("‘A’ bands retain")` the length.
● The `color{violet}("myosin")`, releasing the `color{violet}("ADP and" P_1)` goes back to its relaxed state.
● A new `color{violet}("ATP binds")` and the `color{violet}("cross-bridge is broken.")`
● The ATP is again `color{violet}("hydrolysed")` by the `color{violet}("myosin head")` and the `color{violet}("cycle of cross bridge")` formation and breakage is repeated causing further sliding.
● The process continues till the `color{violet}(Ca^(++))` ions are `color{violet}("pumped back")` to the `color{brown}("sarcoplasmic cisternae")` resulting in the masking of `color{violet}("actin filaments.")`
● This causes the return of `color{violet}("‘Z’ lines")` back to their original position, i.e., `color{brown}("relaxation.")`
● The reaction time of the `color{violet}("fibres")` can vary in `color{violet}("different muscles.")`
● Repeated activation of the `color{violet}("muscles")` can lead to the `color{brown}("accumulation of lactic acid")` due to anaerobic `color{violet}("breakdown of glycogen")` in them, causing fatigue.